LESPEURIL boosts kidney function, facilitates urine excretion, and helps urea excretion
LESPEURIL contains Lespedeza capitata
Lespedeza capitata belongs to the Fabaceae family and grows wild in the eastern United States. The usable parts are blooming plant tops
Each capsule contains Lespedeza capitata 200 mg
CLINICAL STUDIES
There are excellent results in patients with non-renal azotemia and acute post-infection nephritis; good for sub-acute and chronic nephritis and insufficient in patients with end-stage chronic nephritis, which resulted in large lesions of the renal parenchyma.
Weissmann-Netter report that lespedeza capitata leads to improved overall performance and a significant reduction in blood urea, which in some cases is maintained until 15 days after the stop of the treatment.
The good influence of lespedeza has been confirmed in cases of uremia for different reasons, pyelonephritis, renal sclerosis, chronic nephritis, medications, urinary tract cancer, and hepatitis with jaundice. Lespedeza even at doses lower than recommended have effect in all cases, except for non-renal uremia (hepatitis).
Lespedeza:
Reduce significantly the total vascular resistance of the renal afferent and efferent arteries
Decrease urea levels
Increase urinary volume
Normalize acidosis
Increase significantly the renal clearance (16%)
Keep serum electrolytes optimal ratio
SIDE EFFECTS
At therapeutic doses, Lespedeza products are well tolerated. In experimental and clinical studies, lespedeza capitata never had toxic effects and demonstrated excellent tolerability.
PHARMACOLOGICAL ACTIVITY
Lessen Blood urea nitrogen
Harris found that the compensated function of alive nephrons was accentuation and their oxygen consumption increased greatly, so he put forward the hypermetabolism theory that many etiological factors correlate with glomerulonephritis(GN). For example, the overexpression of cytokine, vasoactive substance, and chemotactic factor, the accumulation of extracellular matrix, the proliferation of Mesangial cells, and the hypertrophy of renal tubular epithelial cells are all concerned with important mechanism-oxidative stress.
The mesangial cell, as one of the three inherent cells of the renal glomerulus, has an active physiologic function and also plays an important role in the occurrence and development process of renal glomerulus inflammation and sclerosis. The oxygen radicals, as a signaling molecule, give rise to renal glomerulus sclerosis by activating protein kinase C (PKC) to adjust and control cell proliferation levels.
In the phase of renal glomerulus diseases, the severity of renal tubule interstitial fibrosis can not be ignored. A great deal of oxygen radicals, which can not be eliminated in time, can stimulate renal tubular epithelial cells to excrete a mass of extracellular matrix(ECM), for example, fibronectin(FN), laminin(LN) and colloidal matter, which induce renal interstitium fibrosis.
USAGE
Stimulation of diuresis and application in mild or moderate states of azotemia, with levels of urea by 50 to 100 mg/dl (equivalent to 17,85 -35,90 mmol/l), in cases of mild or moderate renal impairment if the renal parenchyma is preserved enough to respond positively to incentives.
CHEMICAL COMPOSITION
Among the main compounds are catechin tannins, catechol (10%), and flavonoids (1%) identified as O-glycosides and C-glycosides. Lespecapitoside, which is the main active flavonoid is a C- glycoside.
Lespedeza has a selective tropism for renal function and flavonoids determine its action to lessen the body nitrogen as they have a specific chemical structure: sugar-bonded flavon-glucoside as a derivative of glucose (instead of the usual relation O-glucoside). These last much longer glycoside hydrolysis and have longer diuretic action.
LESPECAPITOSIDE
Lespedeza flavonoids have an antioxidation effect as show proliferation inhibition and apoptosis induction of mesangial cells. The latter may be induced by the activation of caspase-3 in a dose-depending way. Lespedeza flavonoids exhibited dose-dependent oxygen radical scavenging activity. This activity was higher than that of vitamin C. Lespedeza compounds could potently counteract oxidative damage to the kidney.Lescapitozide can repair the impaired nephridial tissue by decreasing the overexpression of nuclear factor KappaB and increasing matrix metallopeptidase 9 (MMP-9) protein expression. The result is a lessened extra cellular nephron matrix.
PHARMACOKINETICS
Flavonoids accumulate in organs and tissues directly involved in the transit, metabolism, and excretion of these substances, such as blood, liver, kidneys, gallbladder, and duodenum. Once adopted, the C-glycosides can be found four hours later in the bile and urine and identified as acid phenols. Lespecapitoside is associated with low plasma protein.